Regulation of glucagon‐like peptide‐1 sensitivity by gut microbiota dysbiosis
نویسندگان
چکیده
Gut microbiota dysbiosis reduces expression of GLP-1 receptor (GLP-1R) and neuronal nitric oxide synthase (nNOS) in the enteric nervous system and hampers GLP-1-induced nitric oxide (NO) production through a pattern recognition receptor (PRR)-dependent mechanism, hence preventing activation of the gut-brain-periphery axis for control of insulin secretion and gastric emptying.
منابع مشابه
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عنوان ژورنال:
دوره 9 شماره
صفحات -
تاریخ انتشار 2018